Effect of perioperative opioids on cancer-relevant circulating parameters: mu opioid receptor and TLR4 activation potential, and proteolytic profile. Xie N, Matigian N, Vithanage TD, Gregory K, Nassar ZD, Cabot PJ, Shaw PN, Kirkpatrick CM, Lê Cao KA, Sturgess D & Parat MO. Clin. Cancer Res. 24(10):2319-2327, 2018; doi:10.1158/1078-0432.ccr-18-0172.

Morphine alters the circulating proteolytic profile in mice: functional consequences on cellular migration and invasion. Xie N, Khabbazi S, Nassar ZD, Gregory K, Vithanage T, Anand-Apte B, Cabot PJ, Sturgess D, Shaw PN., & Parat MO. FASEB. 2017; 31(12), 5208-5216. doi:10.1096/fj.201700546R.

Activation of mu-opioid receptor and Toll-like receptor 4 by plasma from morphine-treated mice. Xie N, Gomes FP, Deora V, Gregory K, Vithanage T, Nassar ZD, Cabot PJ,
Sturgess D, Shaw PN, & Parat MO. Brain, Behavior and Immunity. 2017; 61, 244-258. doi:10.1016/j.bbi.2016.12.002.

The TLR4-Active Morphine Metabolite Morphine-3-Glucuronide Does Not Elicit Macrophage Classical Activation In Vitro. Khabbazi S, Xie N, Pu W, Goumon Y, & Parat MO. Frontiers in Pharmacology. 2016; 7, 441. doi:10.3389/fphar.2016.00441.

Book Chapter

Opioid Analgesic Agents and Cancer Cell Biology. Xie N & Parat MO.
Current Anesthesiology Reports. 2015; 5(3), 278-284. doi:10.1007/s40140-015-