Zeyad Nassar – PhD Student 01/2012 to 10/2015

The Role of Caveola–Forming Proteins in Prostate Cancer Angiogenesis and Lymphangiogenesis. PhD Thesis. https://espace.library.uq.edu.au/view/UQ:371637

IPRS/UQ Centenary Scholarship

2015-10-23 14.44.38

Zeyad’s PhD focused on the role in prostate cancer of 2 transmembrane proteins, caveolin-1 and PTRF/cavin1, which are necessary for the formation of caveolae. His project revealed that PTRF/Cavin1 exhibits both caveola-dependent and independent antiangiogenic and antilymphangiogenic functions in prostate cancer cells. He further showed that non-caveolar caveolin-1, whether exogenous or endogenous, enhanced lymphatic endothelial cell proliferation, migration, and differentiation. In contrast, caveolar caveolin-1 did not significantly affect prostate cancer cell lymphangiogenic potential. Caveola-forming protein expression by prostate cancer cells plays significant roles in angiogenesis and lymphangiogenesis pathways, which could be exploited therapeutically.

Productivity during PhD

PhD related publications


Grants and Awards

Current position:  https://www.adelaide.edu.au/directory/zeyad.nassar