Zeyad Nassar – PhD Student 01/2012 to 10/2015
The Role of Caveola–Forming Proteins in Prostate Cancer Angiogenesis and Lymphangiogenesis. PhD Thesis. https://espace.library.uq.edu.au/view/UQ:371637
IPRS/UQ Centenary Scholarship
Zeyad’s PhD focused on the role in prostate cancer of 2 transmembrane proteins, caveolin-1 and PTRF/cavin1, which are necessary for the formation of caveolae. His project revealed that PTRF/Cavin1 exhibits both caveola-dependent and independent antiangiogenic and antilymphangiogenic functions in prostate cancer cells. He further showed that non-caveolar caveolin-1, whether exogenous or endogenous, enhanced lymphatic endothelial cell proliferation, migration, and differentiation. In contrast, caveolar caveolin-1 did not significantly affect prostate cancer cell lymphangiogenic potential. Caveola-forming protein expression by prostate cancer cells plays significant roles in angiogenesis and lymphangiogenesis pathways, which could be exploited therapeutically.
Productivity during PhD
Current position: https://www.adelaide.edu.au/directory/zeyad.nassar