Wenjun’s research article has not only been accepted and published in the Journal of Neuro-Oncology, but was featured on the cover of the June issue of the journal.
Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1.
Pu W, Nassar ZD, Khabbazi S, Xie N, McMahon KA, Parton RG, Riggins GJ, Harris JM, Parat MO.
The article reported that mRNA expression and survival analysis from publicly available data show that expression of caveola-forming proteins caveolin-1 and CAVIN1 is increased in glioblastoma, correlates with expression of urokinase plasminogen activator and gelatinases and is associated with shorter survival. Experimental manipulation of caveolin-1 or CAVIN1 expression in GBM cells indicated that caveolae modulate GBM cell invasion in part via matrix protease expression, but the enzymes and the caveola-forming protein expression changes are not linked by a causal relationship.
The findings of this articles can be found at:
Neurooncol. 2019 Jun;143(2):207-220. doi: 10.1007/s11060-019-03161-8
Congratulations to Wenjun for this great paper and to Zeyad for his help with analysing data from the TCGA and REMBRANDT databases.